This worked for me, but I had to reset the passenger window using the driver's side control and I had to do the sequence twice.

 

I’ve had my 2010 IS350C for 11 years this month and I used the solution in this thread early on in my ownership adventure to reset my passenger side window which was sitting partially open. Textbook symptom and textbook solution.

Today I was heading to the car holding down the unlock button on the fob to lower windows but the driver’s window was still up. (In the morning the window stuck to the weatherstripping a bit as I open the door but things seemed alright otherwise.) I tried lowering the top but is stalled out right after the trunk lid opened and the window remaining up halted the process. Reversed the process and the other windows came up and the trunk closed so I made it home ok and started searching for this thread.

Well, the standard method with extended holding of the switch in either direction didn’t cut it. I took others advice and disconnected the battery (negative lead only) for about 25 minutes. This time, ignition on, I started with pushing the switch down and then up a couple of time but it still didn’t budge. The window was making the very slightest attempt to drop when the door opened but nothing. I shut the door, started the car, and reentered my radio presets, then shut off the car.

Upon opening the door I heard the clunk mentioned by moffutt! Ordinarily you wouldn’t want to hear the kind of clunk, this was music to my ears. I quickly closed the door, the window snugged up! I started it up and pushed the button—the window went down! I cycled the top to make sure it was fully functional, then headed inside to share the good news with anyone still lurking at Club Lexus. I hope this can help others (or at the very least remind me of what I did when it happens again).