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Menu button>>>Start Menu>>>Setup>>>Navi>>>Preset Destinations
From the 2012 450h manual:
Setting up the “Preset Destinations”
If preset destination has been registered, that information can be recalled by using “Preset Destinations” on the “Destination” screen. (See “— Destination search by Preset Destinations” on page 70.)
1. Push the “MENU” button on the Remote Touch. (See “— Remote Touch” on page 5.)
The new RX (Gen III) is such a complex piece of machinery trying to figure something out can be task from time to time. At the top of this Gen III forum the mods (mostly the hard work of Anita) have put together a really good FAQ thread. And it was made pretty easy to search too. So if you're unsure take a look there. If the answer isn't there, let us (moderators) know and we'll get it inserted for future use.