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Wow lots of views and no replies are larger rims looks upon in a bad
light by the Lexus purist?
Anyway....
From what I can gather 22's can be problematic with fitment, bent rims and ride quality, etc.
From the research I've done it seems 20" rims with a reasonable tire and an Eibach drop looks just as good (to me anyway) with a better ride and less trouble.
I was originally going to buy an X5 BMW as I love the look of it but dreaded the reliability and high maintenance issues.
I love the reliability and quality of the RX-350 but don't like the soccer mom, this is your grandma's car feeling it gives me.
If I can toughen it up a bit and get a more aggressive look and feel to this car I'd be completely happy with it.
I see you're new to our community, so welcome to the forum! I think the reason people haven't posted is because there've been quite a few threads on large wheels. My advice, as is that of nearly 100% of our members, is to search first.
But to warn you, you got it on the nose before; the Lexus is designed for people who want a reliable and comfortable ride, so few people go for stance and wheels for this car. This is also pretty evident if you look at the way the wheels, suspension, and even wheel wells are designed. Unless you're ready to drop a few thousand on your wheels and tires, your options will be pretty constricted by offset and width, especially if you're in the stance scene and want your wheels to line up with the body. Also, if you drop the car AND get such large wheels, you'll feel and probably also hear everything on the road, so be prepared for that.
But back to your original question, I'd recommend a search. You'll definitely find everything you need!