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I installed a Pro.Fit Legend bracket with a built-in swivel in my LS next to the radio to hold my now aging Magellan Roadmate GPS and bought an extra power cord that I hid behind the trim and hardwired to the car's accessory outlet wire. It's mounted at about the same level as the factory GPS would be and is easy for my wife to reach. She can't begin to reach a GPS on the windshield without removing her seat belt.
I've been too chicken to use a vent clip on a Lexus - the center vents on my LS are fragile and the vent assembly is over $350 for the part. I don't like the idea of blocking air flow but I haven't tried a vent clip -- maybe it's not that bad. I am liking the idea of getting a vent clip for use in rental cars. Regardless, I've found having the GPS mounted by the radio is far more convenient than having it anyplace on the windshield.
I almost never remove the GPS from its bracket unless it is extremely cold or hot - I just throw a hat or other article of clothing over it to hide it when parking out in public.
Just to follow up, I had my vent clip mounted for almost a year and it did no damage. The proclip comes with adhesive tape to secure the clip in place, keep it from sliding. After a year it easily came off when we picked up our '09 RX. Note the vent I used was the drivers side in the center stack. realy never missed any of the air flow from the vent either, but if becomes a problem, removal of the proclip when the GPS is not used wuld be a snap.