So I have a 2009 LS460 80K miles great car btw I'm coming from an 2006 M45 which had a DVD player in it I did not get the L version of the ls460 but I see the head units going on eBay for a pretty good price will the mark Levison head unit with DVD player work plug n play or is it more to it than that

 

I don't believe this is possible as the wiring/amplifier/speakers are all different. However, try looking on the IS250 forum as I believe there is a member on there who thought it could be done on that car.