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I'll be installing my single sub setup this week hopefully and it just occurred to me if the vibrations of the sub (12" 300 wtts rms) would cause any problems with the oem CD changer (skipping, etc..).
Potholes and normal road vibrations exert many times the force of a typical sub install. You will be fine. And "12" 300 wtts rms" tells us nothing about the capability of your sub.