I have a 2016 is350 with a very annoying vibration coming from the rear window area while driving in 6th gear. My exhaust setup is definitely causing the issue I'm already aware of this. I have a 2.5" catless midpipe with 2.5" axelback muffler delete. The vibration is definitely coming from inside the car it is just very difficult to diagnose not being able to be in the backseat while it's happening. I'm really hoping it's not the rear glass itself. Could it be the ML subwoofer in the rear window? Maybe the sun shade that rolls up? Anyone have any experience with this or any suggestions?

Thanks!

 

You said it yourself, it's the straight pipe. Get an exhaust and the problem will stop.

 

Turns out it was my exhaust hanger being too close to the frame of the car. It would rattle like crazy under high vibration. The hanger has been adjusted and not a rattle since!

FYI, here's a pic of the exhaust Set up

 

Your setup must sound awesome, very clean looking! Props for a local Ont IS350!

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FYI, here's a pic of the exhaust Set up
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I thought for sure it was the vibration the drone causes since you said the noise was "definitely coming from inside the car". Regardless, cheers! Enjoy it!!