So I've been driving my 2006 IS250 awd for a while now and have put a lot of miles on it been great, is now at 210K miles. But as of late has been throwing codes and driving rough and I've been unable to find any info yet that would be a definitive cause of the issues its been having and I would rather not keep replacing parts that aren't broken and don't solve the problem. The codes its throwing is cylinder 2 misfire (P0302) and sometimes multiple cylinder misfire, Intake manifold (P2017), and Catalyst efficiency in bank 1 and 2 (P0420, P0430). It has been driving pretty rough because of the misfire. I would like to know if these codes in combination could help to pinpoint what the issue is? Or if there is further diagnosis I could do with a better code reader and some tests to figure it out? I've already replaced spark plugs and ignition coils and was no help. I've seen everything from carbon buildup in head, to clogged fuel injectors or pump, or even just faulty O2 sensors. If anyone could lead me in the right direction as to where to start with diagnosing and fixing this it would be greatly appreciated! Thanks. Feel free to ask me any further details if need be.