Good Afternoon,
My 2006 IS 350 maybe totalled, hit and run, the car was in great shape 83k miles. Now I'm hoping to find a RX 350 2010- 2015. Wondering if anyone has recommendations, suggestions as to what to avoid, what to look for, anticipated issues at certain mileages. I drove a LS 400 previous to the IS and very happy with the Lexus brand.

 

Welcome to CL. I suggest you read some of the sticky threads at the top of the forum and then try the search feature as you are probably the 100th person to ask that exact question!
You may want to scroll down several pages and glance at the topics to see if anything looks useful.
The RX is one of the most reliable SUVS on the market.
When car shopping check the CarFax as you already know. However you can also join the Lexus Drivers site, link below and enter the VIN of any vehicle you are thinking of buying and it will show you the Lexus dealer service history! Toyota has the same thing. It is great when car shopping.
https://drivers.lexus.com/lexusdrivers
The RX had a refresh in 2013 which greatly improved the infotainment system and navigation and added some safety features. They also took care of a few problems the earlier years had that had to be fixed by service bulletins or recalls. So look for a 2013-2015 model.
I always recommend that the transmission fluid be changed around 50,000 miles to prevent problems later on. I think of it as cheap insurance.

 

^^ What he said.

 

The information Clutchless provided is all you need to put you back in the drivers seat. Good luck in your search!

 

Bigger question fro OP is ... SUV/cross-over vs sedan. Once you decide SUV there are number of Lexus offerings [capability, size, price].

Salim

 

True. It may time to get on the new NX wait list.

 

I have a 2013 RX 350 with 121,000 trouble free miles.The RX s a great car you can't go wrong!