I have owned my 08 RX350 since October last year and am having an unusual problem with the windows. None of them will work at all from any location. They will not go up or down from the driver's door control, nor from each of the door window switches, or the key remote. Also the door lock switch is not working from the driver's door, but does work from the passenger door to lock and unlock the doors. I''m guessing the issue with the windows has got to be a fuse or disconnected wire somewhere, since they will not work from any of the three locations mentioned above. (driver;s door, individual doors, key remote) Anyone got any ideas or had such an issue before?

 

First would be to check the fuses associated with the windows. My second guess is your master switch is possibly shot.

 

In the wiring diagram that I have, there are 8 fuses/fusible links that play a part in the power window operation. They are not all dedicated to the windows. Some of the fuses also supply power to other parts of the car and if blown, you would have additional things not working. I am listing them all.

Located under the hood:
DOOR 1 25 amp
ECU-B 7.5 amp

Located in the dash:
DOOR 2 25 amp
ECU-IG 1 7.5 amp
ECU-ACC 7.5 amp
RR DOOR LH 20 amp
RR DOOR RH 20 amp

This last fuse has a name in the schematic that is not used on the fuse panel covers, so I am not sure of where it is located.
PWR 30 amp

In regards to your problem, the BODY ECU is also a possible cause.