my 2001 GS300 has 80,000 miles. I have change crank shaft, cam shaft seals twice, and in 2 days same leak. Can anyone make any suggestions on any other reason why this could be happening?

 

Are you sure which seals are leaking? Since oil from the cam seals and the VVT-i pulley at the top of the engine will settle at the bottom just at the crank seal, the crank seal may not be leaking, only appear to. Pics would help. Assuming that the seals were installed correctly, it is probably the VVT-i pulley that is leaking. It will spray oil all over the top of the engine inside the timing belt cover making it look like the seals are leaking. It is notorious for leaking in these cars. The O-ring in it deteriorates over time. You can either rebuild it yourself for about $20. Or have someone else rebuild it for you for about $50. Or buy a used rebuilt pulley for about $100 or buy a new one for about $200.

Here's a video on rebuilding it.