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I believe, any engine designed for 5w20 will fail from oil starvation if 5w50 is used.
We are not talking a 50W oil, that is too big a gap/too thick for a engine designed for a 20/30W oil in many cases, a 30W oil will cause no problems as most Lexus/Toyota engine families were originally designed to use a 30W and then went to 20W just for fuel economy.
16W is designed just for fuel economy likely for hybrids with low power/driven lightly and I just would not trust it in higher performing engines especially if you plan on keeping the engine for a while.