what should I look for . the car has 160000 miles and they are asking $10,000.00

Good price but I would check the service history and take it to a shop for a thorough inspection before I purchased it. At the price it would be worth it.

In these types of cases, it is typically a good idea to take it into a Lexus dealer for a PPI (or a Toyota dealer), specifically looking at the water pump and the control arms. The ,ileage alone would NOT scare me off, as these engines and transmissions are relatively bullet-proof.