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Regardless of where you buy, you'll need to do some legwork. The Lexus site can be a pain in the rear and not much help. Just call around and tell the folks what you are looking for. And then let them earn your business as they like to say. Don't forget to get pricing while you are at it. Bottom line. None of that back and forth crap.
Like moose66 said, make sure you get pricing info. Because you can get great deals on IS350 F-sports with ML in California, so if the dealer is unwilling to give you a good discount on your special order 250, you may end up paying almost as much as a 350, and it won't be worth it.