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can't say for sure, since i have a 250, but the member that advised me when i bought my rims drives a 350 and he didnt mention anything about using spacers to clear the brakes. although i just got the F-sport brake upgrades and it barely touches, so i used a 3mm spacer for the fronts now.. hope that helps you.
It should fit on IS350 if you get the correct wheel offset recommendation from PIAA website. I bought a used 19" x18.5 set (knowing it's wrong offset) but ... it works out OK with 10mm spacer. Very happy with it since the tires wall flushes perfectly with the fender even with the spacer.https://www.clublexus.com/gallery/sh...19260&cat=4429