Should have no issues with the off tire provided it is sized the same as the OE tire. As for plugging, you usually can plug a tire unless the issue is with the sidewall. Plugging can be a long or short term solution. But I would not be comfortable on a plugged tire. Especially at a high rate of speed.
'14 Lexus IS350 RWD Obsidian/Gray
'13 Lexus GS450h Nebula Gray Pearl/Black
'06 Nissan Frontier LE Extended Cab - Black/Gray