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HS250h is going to be your best bet for the best combined fuel economy of any luxury vehicle. Another worthy look is the IS250 RWD which is 21 city and 29 hwy but I've been able to get 33-34 mpg easily on the highway. Lexus seems to under rate their fuel economy numbers. For example my 09 ISF is rated 16 city/23 hwy, but I consistently get 23-24 mpg mixed city driving. 28 mpg is the best i've ever achieved on the hwy.
Agreed, all my other Lexus beat the sticker MPG except my SC430. I think I had a lemon.