We recently went on a road trip in our 2024 NX450H+, and there was no opportunity to charge, so we spent several days driving solely on gas.
My calculated gas mileage over 5 fillups was 35.2, 31.6, 33.0, 34.9, and 33.9. Driving was mostly highway/freeway with speed limits as high as 80 and no attempt to increase milage. The weather was hot (90s) so AC on all that time. The trip was about 2500 miles and total miles on the car was about 4000 at the end of the trip.

The car performed well. However, the seats became uncomfortable after a long day of driving, and we were disappointed.
The voice control for both navigation destinations and control of the car was frustrating at time but we are still learning about the car. We had to call the assistant number several times and the AI assistant found our destination where the car could not all but twice. A real person cleared things up twice and that went well but took some time.

Adaptive cruise control worked very well, especially slowing down in curves. Lane assist was, at best, OK; a few times, it pulled in the wrong direction.

The AC performed well in temperatures between 90 and over 100 degrees. I wish there was a MAX AC button to cool the car down when you first get in.

 

Theres a shortcut to that in the popup menu

 

35mpg @ 80mph is reasonable in hybrid mode, when not trying for high mpg. Same for me in a NX350h.

 

Highway mileage for both 350h and 450h+ will always be a little lower than city driving where the battery really helps out. Took my 350h from Ontario Canada to Florida and back and was getting similar mileage, plus we had the car car packed to the gills with our stuff too, so 2 adults and another few 100 pounds of luggage isn't bad in my books. Driving at 80+ mph most of the way it was getting about 1/2 the mileage as our old Nissan Murano did which was around 18-20 mpg at best.