I've been seeing Autel devices featured on Youtube recently. This is good news as it means more shops can own an affordable tool to register sensors to your Lexus without having Techstream software. I went to Autel's site and it appears that for the LS460, these devices work for late 2012 and newer cars but not older ones. The problem of made in China counterfeit sensors that don't always work right is still an issue. If you let your tire shop provide the sensors, you'll have a guarantee or money back. More importantly, no headaches or return visits.

 

Here's my exp re current situation with TPMS sensors and tools.
Autel, beside offering a decent set of affordable scantools (subscription costs are out of the scope of my post), offer a MaxiTPMS system, that consists of a programming Pad (MaxiTPMS Pad, usb device with software, allows to retrieve your original sensor's ID and more) and 'compatible universal sensors' (which fit the rim perfectly, and programmable with Pad). I've personally had two installed on my car. Besides showing -20kpa reading they were pretty solid and cheap solution.
But that was before aliexpress got flooded with 'clones' of Pacific original sensors. I bit the bullet and got a couple of sets. One for pre-12 and one 12+. REALLY cheap (like 25usd for a set of 4 shipped). Had no expectations at all. In fact my current (summer) set got those in. Really good. No difference from oems, pressure readings are correct.
But ultimately it's up to choice which path to use. Choice is good. Not too long ago we (LSers) had almost none.

 

discount tire and costco tire have tools to program the tpms sensor of LS460. Continental brand sensors are used in discount tire.

 

I'd say, if you like to DIY, get Auto scanner for $170 and buy denso from auto store or Lexus sensors from Toyota dealer. OR just have a tire store supply their preferred sensors and pay to have it done. The original sensors seem to be lasting 10 years +-. I believe these tools can also program key fobs as well.