Has anyone purchased Weathertech's 445141 front floorliner mats for a 2016 LS 460 RWD ?

Weathertech's customer service says the 445141 is compatible with the 2016 LS 460 AWD, but not the RWD.

Is there that much of a difference in the AWD and RWD footwell areas ?

 

Yes, the driver side mat for AWD will be smaller and shaped a bit different to account for the larger transmission hump on that side. The AWD mat will fit the RWD but not cover the entire carpet.

 

The drivers mat will be noticeably smaller.

Unfortunately the only option really for all season mats on a RWD 13-17 LS460 are the OEM Lexus ones.

 

I have WeatherTech all-weather floormats in two 2 vehicles (my Sequoia and my wife's RX) and the floorliner in my daughter's RAV4 . When I bought my '15 RWD LS the only sure-fit option I found was the Lexus-branded all-weather mats (as mentioned by SW17LS above) and I have not been disappointed.