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Is it do-able?
I don't see why you can't move harnesses and wires towards the strut towers or relocate them down either towards the firewall or the cam covers.
Exposing the manifold will be the best visual enhancement of the bay.
I did a full tuck myself on my G35 and I have looked over the ISF and it would be a nightmare you would have to break all of the plastic tray and cut and extend a lot of wires. I wouldn't even attempt it unless it's a hard core show car. That being said I think it would be easy to polish everything out.
Toyota and Lexus Join Mille Miglia For The First Time
Slideshow: A five-car lineup spanning more than five decades of Toyota performance and engineering will tackle one of Italy's most celebrated automotive routes.