I'm thinking of changing the center console in my 2014 is300, with the one in the facelift edition. Will this work? Then thought about switching the actual menu / home switches from the old to the new.

 

This can work. Your buttons will be mapped incorrectly but they will work.

 

It will work. I changed mine on my 2014 IS250. I used a console from a 2017 IS. There is a video on YouTube on how to do it. The only button that doesn't work is the back button. Everything else works as it should no problems.