I am getting around 27 mpg on average with my best at 29.3 mpg, and this is the AWD version so it gets pretty good mileage.

 

Like other have mention, if you drive mostly highway, then get the RX350. The rx400h is not very friendly with highway due to its added weight (battery).

My experience: Took a upstate ski trip with my rx400H (06) and my friend's RX330 (04). We decide to do a MPG comparison. We both fill up the tank in the same gas station. After 320miles & 99% highway, my average was 24.1MPG and he got 26.7 after calculation

in NYC city drive, I avg 23mpg and he only got about 16MPG

 

Wanted to check in and mention I got 26.25 mpg driving back from Minnesota to Nebraska (mostly highway, last stretch is on I-29)

I think I would have been around 27 mpg without the interstate part

 

Anyone else getting better mileage on the highway than the city?

I have noticed that on longer trips, I get better mileage. But my commute is few miles. Anyway to get better mileage on short trips?

 

The first 5 minutes or so, the engine has to run to heat the catalytic converter. Therefore, short commutes give poor mileage. Don't know of any way around this except riding a bicycle. The mileage estimated for city driving does not apply to many short trips with cool down during the stops.

 

I've had my 400h for about a week. I've been averaging 32mpg mixed driving. Mostly highway I can still squeeze out 30mpg using hybrid friendly techniques. This is with 250 miles driven so far. I also have a 1995 Civic Vx and developed some hyper-milling techniques that translate to the lexus, I actually dont have to even try that hard to get 32mpg. I think 35-36 is possible, but it may **** off a few people following you!