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Safer bet is to use distilled water and a lint free towel.. Not sure of the composition of the Lexus Nav since we're just starting to get them on our cars up here but using windex might not be the best solution.. Try looking in the owners manual it should have cleaning tips in there I think.. Hope that helps!
Would that NAV screen material be similar to a notebook computer screen? If it is then what the computer stores have for cleaning a notebook computer screen can be used on the NAV.
Just use the cloth... something very soft so you don't scratch it. I don't even use water anymore... the fingermarks come right off with just the cloth.