Rubber seal squeak from driver's door
 

I have noticed a rubber squeak from my driver's door on my 2010 ES 350. It disappears when the rubber is wet so I am thinking perhaps there is a silicon product that I could apply or another fix for this? Any solutions out there?:)

Which rubber seal exactly is squeaking? There are a few on the door. It could possibly need door adjustment so to get rid of it rather than lube...

You can try einszett gummi pflege stift, (yes that's spelled correctly!) I don't know if it will solve your problem as Igzy says but people swear by it.

the rubbing noise seems to be coming from overhead the door not the rubber after all? Anyone out there that had similar problems?

I used a silicon spray lubricant and wiped it on all the rubber seals and the surfaces they seal against and it got rid of the rubber seal sound on my door. If it is overhead, it might be the seal for the sunroof making similar sounds. You can clean/lube that seal and sealing surfaces the same way except the rear seal will be difficult to reach.