How much coolant/water mix in gallons will I need to flush and refill 2003 es300?

 

if you do it with distilled H20, you can figure it out. open all the drains, fill with distilled. do this three times, then you have water in your engine and can use straight coolant to fill and get close to 50/50.

 

This depends upon whether you are just draining the radiator and refilling (less than a gallon), or trying to empty the whole system, including heater core. That's like 2.5 gallons total capacity, I think ~9.3 qts.

What are you trying to do, complete flush with block drains opened and heater core flushed out, or radiator drain/fill, or...?