I have a 2005 RX330 made in japan (no sunroof). 152,000 miles. Purchased new. Other than premature front brake wear at 42,000 miles (warped discs), general wear and tear (brakes, tires, batteries, wipers, bulbs), changing spark plugs (at 140,000 miles, could have carried on a while longer), 2-3 recalls, and the proverbial timing belt/water pump, nothing has broken down. No engine codes, not consuming any oil. At this point, suspension needs an overhaul due to wear and tear (I'd classify my usage as heavy duty) - nothing replaced to date. Most reliable vehicle I've ever owned - probably helped that I don't have a sunroof, electric tailgate, nav or air suspension. I cannot tell you if the Canadian made 330 or the 350 are as reliable (its fair to say, they couldn't possibly be more reliable).
In my opinion, the key to a successful purchase is low mileage, not the year. As well, you'll want to inspect the suspension thoroughly. Not only to get a sense of the vehicle's travels but also to give you an idea of future maintenance. Hope this helps.
Last edited by pablo87; 10-10-14 at 09:30 AM..