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Anyone have any experience or know if this rack will work on the RX350.
Personally, no. Worked in a bike shop for many years and have had customers that wanted a similar style on a minivan or SUV, owner didn't want the responsibility/liability of the rear window breaking if not installed correctly.
Reasons not to: Window isn't meant to have a load on it like that, fine for a trunk.
Not always easy to get into the hatch area.
The top straps need to secure to the hatch opening above the rear spoiler, I'd be worried it would crack.
Check with a Saris compatibility guide or a reputable bike shop for their opinion.