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I checked online and it seems the only closet thing I found was someone using rx300 wheels. it seems by looking at the wheel specs it might be just plug in and play. though i'm worried about the offset and will it clear the front brakes. i plan to run 245/45/18 the offset for the rx350 wheels seems to be 35 and the ls400 is 45. i wouldn't be dropped to many road hazards here. to many pot holes to speed bumps if that plays any factor to it.
interesting proposition, and one that i have not seen yet though i've thought about it myself over the years.
since the RX is a FWD based chassis, likely the wheels are designed to that so most likely the wheels will not clear the front brakes of the LS outright. you may need spacers at the minimum.
offset is only part of the equation, where wheel/spoke design is the other half.
This is rx350 rims from a 04-09. Those are 18in wheels. This is where i got my idea. Since a 2009 fits shouldn't a 2010 fit? The other difference is I have a 2000 vs what looks like maybe a 1996. just guessing.