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they will fit but look awkward. they are not staggered fitment and the offsets are a little high, even if they were for fronts only. 19x8 +30 would be a lot more flush but they are +50 for the front. having 19x8 +50 for rear would take away from the classy look of BBS LM's.
there are a few IS250AWD that have staggered wheels.
Yeah me being one of them . Time for a change. Something I can sell with the car...like stock "replacements" if you will lol. Thought my link would be perfect.
Run some large spacers. Personally i don't like that style wheel its going to look very small on the IS. And they are kind of expensive for a set of 18"s that arent brand new. I'd keep looking if i were you.
I dont know how the width of the rim effects the clearance, but having 8.5" wide front with +38 offset (18inch), I barely have 1/4" clearance ,if that, between front face of the caliper and the rim. Radial clearance would not be a problem. You may need spacers. Good luck!
Here is my set up: 18inch, 8.5f x 9.5r, both being +38 offset.