Mtc725

I recently purchased the 2013 ES300H and I am looking to replace the stock wheels on them. I am debating between 20's and 22's. My only concern is if 22's will fit without rubbing issues, I know most people are not a fan of big wheels on a Lexus and that the bigger wheels will reduce the MPG, but I am coming from a Mercedes C300 which on a good day gave me 280 miles to a full tank!!!!! With the 640 I am averaging now, the reduction in MPG won't be a factor.

Anything help is appreciated