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The most popular fitment for the IS250 AWD is an 8" or 8.5" wide wheel using a +40mm offset. 9.5" and 10" wide wheels will require modifications to fit.
Was there a particular wheel you were interested in?
It looks like you are interested in 20". Most wheels in this size will be 8.5" wide and will offer a 40mm offset. Discount Tire Direct and Tire Rack would be a good place to start looking at wheel options.