It will be due for plugs as well. You'll need to start thinking about struts and shocks, bearings. A complete fluid change, oil, trans, radiator, brakes, power steering, transfer case if AWD. These things respond well to maintenance, take care of it and you may double that mileage.
Register it at Lexus to see all the Lexus performed maintenance since new.
This work doesn't need to be done all t once, just schedule it in and take care of it over time.
Good luck and welcome to the forum.