I'm not trying to stir the pot I'm just adding my experiences as well as some limited understanding to the post. I've had two exhaust designs that I didn't quite get right (quiet enough).
The reason that a resonator will knock down more of the higher frequencies is because more of the anti-nodes of the sound wave are contained within the resonator. So the longer your resonator the lower the frequency that a resonator can contain given all other things the same.
A chambered muffler takes sound energy converts it to mechanical energy (movement of the baffles), and cancels some of the wave on itself (I'm not convinced a lot of that happens). If someone took a well-designed baffled muffler and made it out of 1/2" thick steel it wouldn't do as good of a job.
On my H22a Prelude I put a highflow cat, the largest resonator and the largest Magnaflow that would physically fit in the two locations. It was way louder than what I was wanting (sounded pretty sweet, but I don't want to hear the car unless I'm popping VTEC).
On my Chevy K30 I put the largest Flowmaster I could get on and it's too loud too (sounds pretty sweet, but not what I'm going for). My Silverado has the stock cat and a long glass-pack (resonator) and it sounds better than either of the systems I put together.
So the answer is it depends on a lot of different things, pipe size, length, muffler type and quality, motor displacement, number of cylinders, and red-line are just a few. The best thing you can do is go listen to lots of cars and find a sound that you like and copy that. That's not usually possible, so you have to use the advice of people and your own judgment. The great thing about the LS is that you can just start disconnecting things to get a feel for how it would sound in a given situation.