Barny

The door lock actuators are prone to failure due to the small motor failing. Since the part is $325 many of us have sought to repair it ourselves. Our forum has a few threads and DIYs, the attached file has more details shown in three DIYs:
1. Removing the door trim panel.
2. Removing the lock actuator.
3. Repairing the lock actuator.
I hope this helps,
Bruce

Clay Easto

Very cool, thanks for doing this. I have had two door lock actuators replaced under the Lexus extended warranty.

mandyfig

Wow great work on this DIY!

LMN_Sins

Would this work the same for a 2009 is 250? Thanks...

7tisix

I have a few tips for 2010 IS350.
I ordered Central Door Lock Actuator Motor FC-280PC-22125 FLAT SHAFT

Tools: Torx T30, 10mm socket, phillips and various sized flat head, razor blade, plastic retainer tool.
The exterior manual door lock removal is only required on driver's side front door.
When removing the trim panel, some foam washers will fall off the plastic retainers. I suspect these suppress door rattle. You may want to replace or reuse them.
There is a bolt about a foot under the actuator electrical plug for the window rail. Removing this bolt makes taking the actuator out and reinstalling much easier. Just make sure you raise the window first, and reinstall the bolt before lowering the window.
There is no need to remove the whole clear plastic assembly. You only need to expose the opening closest to the actuator.
Before removing the metal latch assembly from the actuator, there is a foam weather strip that is in the way. Don't remove it. Use a razor and dissect it at the plastic seam and you won't need additional weather stripping.
Move the actuator cover clips as little as possible to open. Use a flat head screw driver and place in the seam as you work around the unit gently prying the clips.
There is a small piece of black tape on the motor. Place it on the new motor.
There is a white plastic piece you must line up when closing unit. You can see it through the opening. Use a metal hook to line it up.
Test the unit once reassembled. Simulate a closed door by pressing the black latch shut. Pull on the rod opening to see if it releases. Now shut the latch again and simulate a locked door by manipulating the lock cable and make sure the door latch doesn't release.
Don't forget to reinsert the door handle rod into the actuator.
​​​​​​Install the plastic door trim latch cover before reinstalling the trim panel.

These videos will help with the actuator even though they are for a Tacoma:
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7tisix

Yes. It will work on all gen2 IS models.