OK, I'm an idiot, my wife inadvertently pushed the window lock button. It locks the 3 passenger windows in the down position.
Tx to Bell/Scottsdale Lexus for the information.
We'd never used the button before, forgotten all about it, but no excuses.
2011 Porsche Cayman
2010 IS250 C
2008 Kawasaki Versys
2007 Honda Ridgeline
1996 Bayliner 4087