so both my sister and i both have a 06 gs300 and her car is doing the same thing. So i called over to south county lexus and spoke with Doug my service writter, and he said that they recently released an extended warranty for some O-ring on the pistons for this car. i think he called it a Rough Ride recall, but he said that very well can be the issue causing that. its something to look into. im leaving to take my sisters car in about 15 min. ill post up results when i get them ::fingers crossed::
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I have the exact same problem you are having with my 2006 GS 300 RWD. It wont **** passed 4 or 5th gear. I have 100,000 miles. My dealer attempted to get fixed for me for free but the manager declined because he said my car hasn't received regular maintenance at Lexus. Now im just stuck as I don't have $4000 to get it repaired.
Bypass the dealer, and speak to Lexus CS directly.
It's bollocks that the car hasn't seen the dealership's service bay as having anything to do with the transmission going south - it's a lifetime fluid, and barring any loss of fluid from leaking gasket around the pan, that puts that stupid comment in its place.
Are we to presume you've had the car serviced elsewhere regularly, etc?
If Lexus won't play ball, then source a replacement pre-owned unit, and it'll cost a lot less than $4K.
Alternatively find a good transmission specialist, and see what they have to say.