I don't know how to fix cars so I depend of forums. =D I have a 2000 Lexus GS300 and all the other doors lock except for the front passenger door. You have to manually click the switch on the door in order for it to lock. I think because of that, the door won't unlock with the button on the key, instead, it requires inserting the key and then unlocking by turning the key.
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I purchased 4 motors from Ebay for $38 shipped (they are more expensive now than before, from what I read, but this is not too bad, compared to $280 for the lock assembly). Look for the http://cgi.ebay.com/ebaymotors/ws/eB...OU%3AUS%3A1123
What you are looking for is Item:4-pk Lexus/Toy Door Actuator repl Mabuchi FC280PC-22125.
Make sure you order the motor without the brass coupling on the metal rod - you will have to take off the existing coupling from the bad motor(s). You might as well get some grease that is used for plastic parts (I didn't).
I replaced a bad motor in the front passenger door. After you read the thread for instructions on how to take off the door panel and lock assembly, look for my post in the end of the thread on testing the lock assembly (both mechanically and with a key fob) before you put it back in - it may save you some time and headache. Overall, a very doable job if you use your head and don't have $1000 to have it done by the dealer.
There is a ton on information on this forum on this issue since it is very common; almost inevitable over time.
This an easy DIY if you are just a little mechanically inclined. You can get actuators from eBay for about $100. You can get the motors that go in the actuator for about $20 for 4. The motor is what goes bad, not the whole actuator. If you replace the actuator it'll take about 30 minutes, If you replace the motor in the actuator, add another 20 minutes. Good luck.