Properly fitted wheels and tires do not alter the suspension geometry or function. They will, to a certain extent, change the handling characteristics due to the different behavioral characterstics of certain wheel/tire combinations.
Although in theory it can be slightly affected, in a nutshell, NO wheel and tire combination will change your alignment. The alignment is a function of the control arms, steering arms and spindles, which (to a certain extent) do not have any play in them which is what would alter suspension geometry. Of course, if your tires are sticking out 2" past the fenders you will have handling issues, but it is not because of a change in alignment or suspension settings.
Todd M.
TM Engineering
http://www.tmengineering.net